IMIDAZOLE-ZINC CATALYSTS FOR RNA HYDROLYSIS

Authors
CHU FY SMITH J LYNCH VM ANSLYN EV
Citation
Fy. Chu et al., IMIDAZOLE-ZINC CATALYSTS FOR RNA HYDROLYSIS, Inorganic chemistry, 34(22), 1995, pp. 5689
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Inorganic chemistry → ACNP
ISSN journal
00201669
Volume
34
Issue
22
Year of publication
1995
Database
ISI
SICI code
0020-1669(1995)34:22<5689:ICFRH>2.0.ZU;2-O
Abstract
Zinc-imidazole complexes are reported to enhance the rate of hydrolysi s of RNA to nearly the same extent as zinc-amine complexes and zinc al one. The imidazole containing ligands are easily synthesized. Ligand 1 binds zinc with an association constant of (9 +/- 1) x 10(4) M(-1), a nd possesses a metal bound water with a pK(a) of 7.4 +/- 0.1. These zi nc complexes should prove quite useful in elucidating the mechanism of Zn-OH-promoted RNA hydrolysis.