Gj. Locker et al., LETHAL WATERHOUSE-FRIDERICHSEN SYNDROME IN POSTTRAUMATIC ASPLENIA, The journal of trauma, injury, infection, and critical care, 39(4), 1995, pp. 784-786
We herein report a case of fulminant lethal Waterhouse-Friderichsen sy
ndrome in an elderly female patient seven years after posttraumatic sp
lenectomy. In contrast to various reports, this patient had not been v
accinated against Streptococcus pneumoniae, Neisseria meningitidis, or
Haemophilus influenzae, respectively, although infections with these
microorganisms are known to cause the main lethal diseases in asplenic
patients, Again, we recommend obligatory vaccinations against the men
tioned bacteria for it is known that this decreases the risk of fatal
septic events in these patients. To optimize prevention, it is imperat
ive to vaccinate patients undergoing splenectomy before discharge from
hospital.