EFFECT OF MULTIPLE-DOSE ACTIVATED-CHARCOAL ON THE CLEARANCE OF HIGH-DOSE INTRAVENOUS ASPIRIN IN A PORCINE MODEL

Study objective: To study the effect of multiple-dose activated charco al (MDAC) on salicylate clearance in pigs given high-dose IV aspirin. Design: In a crossover design, six fasted pigs received 300 mg/kg IV a spirin followed by no treatment or MDAC (1 g/kg hourly for 6 doses by gastrostomy). Serum salicylate samples were obtained every 30 minutes for 6 hours. Results: The mean peak salicylate concentrations were 47. 4+/-6.2 mg/dL and 48.4+/-3.9 mg/dL (P=.74), and the areas under the ti me-serum salicylate concentration curve over 6 hours were 171,000+/-24 ,000 mg . minute/L and 188,000+/-18,000 mg . minute/L for the control and treatment arms, respectively (P=.22). This study had a 90% power t o detect a 30% difference between arms. Conclusion: MDAC does not enha nce the clearance of salicylate after administration of high-dose IV a spirin.