M. Denegri et al., TREATMENT OF ELECTRICAL STATUS EPILEPTICUS BY SHORT DIAZEPAM (DZP) CYCLES AFTER DZP RECTAL BOLUS TEST, Brain & development, 17(5), 1995, pp. 330-333
The effects of rapid rectal diazepam introduction (DZP test) were inve
stigated in 43 patients (age range 5 months-14 years) with electrical
status epilepticus (ESE) undergoing EEG monitoring, A remission of the
paroxysmal activity was obtained in 58% of cases, a negative response
in 42%, particularly in hypsarrhythmic patterns, DZP test responders
were aged over 12 months with organized paroxysmal EEG patterns, in pa
rticular with ESE during sleep (ESES), The patients who responded to t
he DZP test underwent short cycles (3-4 weeks) of relatively high dosa
ge DZP (0.5-0.75 mg/kg), The response to treatment was positive in 64%
, particularly in ESES conditions, 56% of responders to the DZP test b
ut not to DZP therapy (five out of nine patients) presented a signific
ant mental retardation; maturational factors were also likely to be pr
esent.