We describe a patient with advanced acquired immunodeficiency syndrome
(AIDS) who presented with evidence of carditis, arthritis, and chorea
in the setting of fever, and serologic evidence for recent streptococ
cal infection. Several features atypical for rheumatic fever were pres
ent and included persistently high titer of antistreptolysin O, the si
multaneous occurrence of chorea and arthritis, and the presence of cho
rea in a sexually mature adult man. The differential diagnosis of arth
ritis in a host at risk for human immunodeficiency virus should be exp
anded to include acute rheumatic fever, which may manifest atypical fe
atures.