Two patients are described with reproducible cardiac asystole post-exe
rcise. No structural heart disease was demonstrable. At autonomic func
tion testing no abnormal responses were noted. Also, head-up tilt test
s were normal. However, electrophysiologic testing and heart rate vari
ability during 24-h Holter monitoring were indicative of a high vagal
tone in both patients. The findings suggest that post-exertional asyst
ole may not be due solely to a vasovagal mechanism; excessive rebound
vagotonia per se may also play a role.