ANTICANCER AND ANTIOXIDANT ACTIVITY OF SYNTHETIC CHALCONES AND RELATED-COMPOUNDS

Authors
ANTO RJ SUKUMARAN K KUTTAN G RAO MNA SUBBARAJU V KUTTAN R
Citation
Rj. Anto et al., ANTICANCER AND ANTIOXIDANT ACTIVITY OF SYNTHETIC CHALCONES AND RELATED-COMPOUNDS, Cancer letters, 97(1), 1995, pp. 33-37
Citations number
16
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
97
Issue
1
Year of publication
1995
Pages
33 - 37
Database
ISI
SICI code
0304-3835(1995)97:1<33:AAAAOS>2.0.ZU;2-U
Abstract
Nineteen synthetic chalcones and ten structurally related compounds we re investigated for their cytotoxic, tumour reducing and antioxidant a ctivities. Methyl and hydroxy substituted chalcones were found to be c ytotoxic in vitro whereas only hydroxy substituted chalcones could red uce ascites tumour in animals. Although most of the compounds analysed showed antioxidant activity, hydroxy and methyl substituted compounds were found to be the most potent antioxidants.