KERATINOCYTE GROWTH-FACTOR - AN ANDROGEN-REGULATED MEDIATOR OF STROMAL EPITHELIAL INTERACTIONS IN THE PROSTATE

Authors
Citation
Dm. Peehl et Js. Rubin, KERATINOCYTE GROWTH-FACTOR - AN ANDROGEN-REGULATED MEDIATOR OF STROMAL EPITHELIAL INTERACTIONS IN THE PROSTATE, World journal of urology, 13(5), 1995, pp. 312-317
Citations number
43
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
07244983
Volume
13
Issue
5
Year of publication
1995
Pages
312 - 317
Database
ISI
SICI code
0724-4983(1995)13:5<312:KG-AAM>2.0.ZU;2-Y
Abstract
Members of the fibroblast growth factor (FGF) family are important gro wth-regulatory elements. Of the FGFs, keratinocyte growth factor (KGF) appears to have unique properties that implicate it as a paracrine fa ctor in the prostate. Two KGF transcripts (approximate to 2.4 and 5.0 kb) encode a protein of approximate to 22 kDa. In contrast to several other members of the FGF family, KGF has a signal peptide and is activ ely secreted. Cellular response to KGF is mediated by a specific recep tor that is transcribed from an alternately spliced variant of the FGF type 2 receptor (FGFR-2). KGF transcripts have been detected in prost atic tissues and in stromal cells cultured from rat and human prostate s as well as in a variety of stromal cells derived from other organs. Prostatic epithelial cells and numerous other types of epithelial cell s are targets of KGF's mitogenic activity. Several factors involved in wound healing regulate the expression of KGF, but androgen regulation of KGF is of greatest relevance to the role of KGF in the prostate. C urrent efforts to localize and manipulate KGF activity in vivo should reveal the significance of KGF expression and function in the prostate and in other organs.