ANTI-OXIDIZED LDL ANTIBODIES AND ANTIPHOSPHOLIPID ANTIBODIES IN HEALTHY-SUBJECTS - RELATIONSHIP WITH LIPOPROTEIN-RELATED AND OXIDATION-RELATED ANALYTES

IgG autoantibodies against malondialdehyde-modified LDL (alpha oxLDL), antiphospholipid antibodies (APA) and oxidation- and lipoprotein-rela ted analytes were assayed in sera from healthy subjects (51 males, 115 females, aged 22-63 years). alpha OxLDL levels were associated (P<0.0 3) with IgG alpha cardiolipin (r=0.18), IgM alpha cardiolipin (r=0.17) and IgM alpha phosphatidylserine (r=0.16) but not with age, cholester ol, triglyceride, apolipoproteins B and AI, lipoprotein(a), lipid pero xides, ceruloplasmin, copper, ferritin, transferrin or iron. APA level s were inversely associated with levels of both oxidation- and lipopro tein-related analytes. Ferritin (3.5%) and alpha oxLDL (1.4%) contribu ted independently to variation in IgG alpha cardiolipin levels, and ap o B (2%) to variation in IgM alpha cardiolipin levels. These associati ons are small, indicating that there are no major biological associati ons between the measured variables. The lack of association between al pha oxLDL and lipoprotein- or oxidation-related analytes suggests that the relevant antigen is not in serum. (C) 1995 Academic Press Limited