HUMAN DNA-ACTIVATED PROTEIN-KINASE (DNA-PK) IS HOMOLOGOUS TO PHOSPHATIDYLINOSITOL KINASES

Authors
POLTORATSKY VP SHI XY YORK JD LIEBER MR CARTER TH
Citation
Vp. Poltoratsky et al., HUMAN DNA-ACTIVATED PROTEIN-KINASE (DNA-PK) IS HOMOLOGOUS TO PHOSPHATIDYLINOSITOL KINASES, The Journal of immunology, 155(10), 1995, pp. 4529-4533
Citations number
51
Categorie Soggetti
Immunology
Journal title
The Journal of immunology
ISSN journal
00221767 → ACNP
Volume
155
Issue
10
Year of publication
1995
Pages
4529 - 4533
Database
ISI
SICI code
0022-1767(1995)155:10<4529:HDP(IH>2.0.ZU;2-M
Abstract
DNA-activated protein kinase (DNA-PK) is a serine/threonine protein ki nase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain t he DNA-PK gene complement the murine scid defect, indicating that DNA- PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 10 0 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatid ylinositol kinases.