EFFECTS OF CAFFEINE AND THEOPHYLLINE ON PROSTAGLANDIN PRODUCTION BY GUINEA-PIG ENDOMETRIUM

Authors
NADERALI EK POYSER NL
Citation
Ek. Naderali et Nl. Poyser, EFFECTS OF CAFFEINE AND THEOPHYLLINE ON PROSTAGLANDIN PRODUCTION BY GUINEA-PIG ENDOMETRIUM, Prostaglandins, leukotrienes and essential fatty acids, 56(1), 1997, pp. 63-67
Citations number
18
Categorie Soggetti
Endocrynology & Metabolism",Biology
Journal title
Prostaglandins, leukotrienes and essential fatty acids → ACNP
ISSN journal
09523278
Volume
56
Issue
1
Year of publication
1997
Pages
63 - 67
Database
ISI
SICI code
0952-3278(1997)56:1<63:EOCATO>2.0.ZU;2-8
Abstract
Caffeine and theophylline increased prostaglandin output from day 7 an d day 15 guinea-pig endometrium in culture. Ryanodine and forskolin ha d no effect on endometrial prostaglandin output. These results show th at methylxanthines stimulate endometrial prostaglandin synthesis. Howe ver, the intracellular mechanisms involved apparently do not entail an increase in the intracellular free calcium concentration by activatio n of a ryanodine-sensitive receptor or an increase in the cyclic AMP c oncentration.