NOVEL DRUG-DELIVERY SYSTEM BY CHITIN DERIVATIVE

A porous chitin foam was regenerated from chitin dope in calcium chlor ide dihydrate saturated methanol. The porous chitin foam was shown to have cationic property, because chitin foam tended to adsorb anionic d yes through ionic binding and hydrophobic interaction. A pendant type of polymeric drug was prepared applying peptide spacer composed of phe nylalanine at amino end and two step hydrolyses of polymeric drug were shown to release active drug at the final step using lysozyme and chy motrypsin in vitro.