S. Suemaru et al., CEREBROSPINAL-FLUID CORTICOTROPIN-RELEASING HORMONE IN NEURODEGENERATIVE DISEASES - REDUCTION IN SPINOCEREBELLAR DEGENERATION, Life sciences, 57(24), 1995, pp. 2231-2235
Citations number
31
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Levels of corticotropin-releasing hormone (CRH) in cerebrospinal fluid
(CSF) were examined in patients with spinocerebellar degeneration (SC
D) including olivopontocerebellar atrophy (OPCA), dentato-rubropallido
luysian atrophy (DRPLA) and Friedreich's ataxia, Parkinson's disease (
PD) and senile dementia of the Alzheimer type (SDAT), and normal aged
subjects. CRH concentrations in CSF Here significantly reduced in SCD
compared to SDAT PD and normal aged subjects. It is likely that degene
ration not only of the cerebral cortex and the limbic system but also
of the subcortical structures such as the brainstem and the cerebellum
alters levels of CRH in CSF. Together with the recent anatomical and
physiological evidence, the results suggest pathophysiological relevan
ce of CRH for the cerebellar symptoms in SCD.