THE RAT MODEL OF TARDIVE-DYSKINESIA - RELATIONSHIP BETWEEN VACUOUS CHEWING MOVEMENTS AND GROSS MOTOR-ACTIVITY DURING ACUTE AND LONG-TERM HALOPERIDOL TREATMENT
Oa. Andreassen et Ha. Jorgensen, THE RAT MODEL OF TARDIVE-DYSKINESIA - RELATIONSHIP BETWEEN VACUOUS CHEWING MOVEMENTS AND GROSS MOTOR-ACTIVITY DURING ACUTE AND LONG-TERM HALOPERIDOL TREATMENT, Life sciences, 57(24), 1995, pp. 2263-2272
Citations number
27
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Tardive dyskinesia (TD) is a serious side-effect of neuroleptic treatm
ent. In order to describe and analyse more thoroughly the rat model of
TD, the behavior of the rats during cage testing was studied after ac
ute and during long-term haloperidol (HAL) treatment. Rats were inject
ed with HAL TP in an acute experiment, and in a long-term experiment,
rats were treated for 4-12 months with HAL decanoate LM. Control rats
received saline or sesame oil. The behavior was videotaped one h after
the IP injection in the acute experiment, and at intervals during the
long-term experiment. The putative TD analogue vacuous chewing moveme
nts (VCM), the general behavior and the type of behavior occurring sim
ultaneously with VCM, were scored. Long-term (> 4 months) HAL treatmen
t increased VCM but did not change the general behavior. The single IP
injection of HAL markedly reduced locomotion in addition to increasin
g VCM. Both in the acute and in the long-term experiment, VCM appeared
more frequently when the gross motor activity was low, indicating an
intrinsic incompatibility between gross motor activity and VCM. Howeve
r, in the long-term experiment, the distribution of VCM in the differe
nt categories of behavior was the same in OIL and HAL treated rats. Th
is shows that cage-observed VCM in rats induced by long-term HAL treat
ment cannot be an artifact due to reduced locomotion. Thereby, an impo
rtant argument against cage-observed VCM as a rat model of TD seems to
be disproved.