A GENERAL-APPROACH TO 3-AMINOISOQUINOLINE, ITS N-MONO-DISUBSTITUTED AND N,N-DISUBSTITUTED DERIVATIVES

Authors
ZDROJEWSKI T JONCZYK A
Citation
T. Zdrojewski et A. Jonczyk, A GENERAL-APPROACH TO 3-AMINOISOQUINOLINE, ITS N-MONO-DISUBSTITUTED AND N,N-DISUBSTITUTED DERIVATIVES, Tetrahedron, 51(45), 1995, pp. 12439-12444
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
45
Year of publication
1995
Pages
12439 - 12444
Database
ISI
SICI code
0040-4020(1995)51:45<12439:AGT3IN>2.0.ZU;2-P
Abstract
Condensation of 2-cyanomethyl benzaldehydes 1 with 2 (ammonia, primary or secondary amines) carried out in the presence of a catalytic amoun t of trifluoroacetic acid afforded 3-aminoisoquinolines 3. In the case of primary amines azomethines 4 were formed at first; they dissociate d and subsequently yielded 3 in a rather slow process.