Local corticosteroid injection therapy may be considered for many cond
itions commonly treated by the primary care physician. Chronic overuse
and flawed biomechanics may lead to inflammation in areas easily acce
ssible to injected local corticosteroids, including bursae, tendon she
aths and joints. It is generally preferable to mix the steroid prepara
tion with an anesthetic agent to minimize the injection pain, provide
immediate symptom relief and confirm the diagnosis. Local complication
s of corticosteroid injection include tendon and ligament weakening, b
acterial infections of joints and related structures, and cosmetically
significant depigmentation and subcutaneous tissue atrophy. Systemic
complications are rare but reportedly include hyperglycemia and adrena
l axis suppression.