SOLID-PHASE SYNTHESIS OF A NUCLEOPEPTIDE FROM THE LINKING SITE OF ADENOVIRUS-2 NUCLEOPROTEIN, -SER(P5'CATCAT)-GLY-ASP- - CONVERGENT VERSUS STEPWISE STRATEGY

The synthesis of a nucleopeptide with the sequence -Ser(p(5')CATCAT)-G ly-Asp- has been undertaken by either convergent or stepwise solid-pha se strategies, both of which use base-labile permanent protecting grou ps, The coupling of phosphitylated protected peptides onto oligonucleo tide-resins did not afford the desired nucleopeptide, which was nevert heless obtained after oligonucleotide elongation at the hydroxyl group of the resin-bound peptide and deprotection under mild basic conditio ns, A preliminary study on the stability of different nucleopeptides t o bases is also reported.