LIVER INFLAMMATION AND ACUTE RESPIRATORY-DISTRESS SYNDROME IN A PATIENT RECEIVING HEPATITIS-A VACCINE - A POSSIBLE RELATIONSHIP

Authors
RANIERI VM DELLERBA A GENTILE A BRUNO F LAGIOIA V SPAGNOLO A SACCO R CARUSO G ANTONACI S SCHIRALDI O BRIENZA A
Citation
Vm. Ranieri et al., LIVER INFLAMMATION AND ACUTE RESPIRATORY-DISTRESS SYNDROME IN A PATIENT RECEIVING HEPATITIS-A VACCINE - A POSSIBLE RELATIONSHIP, Intensive care medicine, 23(1), 1997, pp. 119-121
Citations number
10
Categorie Soggetti
Emergency Medicine & Critical Care
Journal title
Intensive care medicine → ACNP
ISSN journal
03424642
Volume
23
Issue
1
Year of publication
1997
Pages
119 - 121
Database
ISI
SICI code
0342-4642(1997)23:1<119:LIAARS>2.0.ZU;2-3
Abstract
We describe a patient in whom clinical evidence of liver and lung dysf unction developed after he received the second dose of recombinant hep atitis B vaccine, despite no serologic evidence of viral hepatitis, Ho wever, liver biopsy specimens demonstrated both surface antigens and c ore antigens, possibly indicating silent hepatitis B virus infection. A search for an infective etiology for the patient's subsequent clinic al deterioration in lung function did not yield pathogens; postmortem examination revealed evidence of immune complex-mediated organ injury in the liver, lungs, and kidneys.