SYNTHESIS OF 6-O-PALMITOYL L-ASCORBIC-ACID CATALYZED BY CANDIDA-ANTARTICA LIPASE

Authors
HUMEAU C GIRARDIN M COULON D MICLO A
Citation
C. Humeau et al., SYNTHESIS OF 6-O-PALMITOYL L-ASCORBIC-ACID CATALYZED BY CANDIDA-ANTARTICA LIPASE, Biotechnology letters, 17(10), 1995, pp. 1091-1094
Citations number
14
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
17
Issue
10
Year of publication
1995
Pages
1091 - 1094
Database
ISI
SICI code
0141-5492(1995)17:10<1091:SO6LCB>2.0.ZU;2-U
Abstract
The synthesis of ascorbyl palmitate was achieved in non aqueous medium with an immobilized lipase from Candida antartica as biocatalyst. Thi s enzymatic synthesis is perfectly regioselective. When palmitic acid methyl ester is used as acyl donor, 68% of ascorbic acid is converted against 56% in the presence of palmitic acid. These optimal values wer e obtained when the initial molar ratio of ascorbic acid to acyl donor is 1:5.