PARANEOPLASTIC NEUROLOGIC SYNDROMES - CLA SSIFICATION AND DIAGNOSIS

Paraneoplastic neurologic syndromes may be the presenting symptoms of cancer or appear during the course of the disease. Current knowledge o f paraneoplastic syndromes is discussed on the basis of Henson and Uri ch's classification. The recognition of antineuronal antibodies in som e neurologic paraneoplastic syndromes has had an impact on diagnostic possibilities. Additionally, there are new considerations relating to pathogenesis and therapy. Although the value and diagnostic yield of a ntineuronal antibodies are the subject of major discussion, they are a lready of significant diagnostic value in the diagnosis of paraneoplas tic neurologic syndromes.