KILLING ACTIVITY OF CEFPIROME AGAINST PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE ISOLATES FROM PATIENTS WITH MENINGITIS IN A PHARMACODYNAMIC MODEL SIMULATING THE CEREBROSPINAL-FLUID CONCENTRATION PROFILE
F. Fitoussi et al., KILLING ACTIVITY OF CEFPIROME AGAINST PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE ISOLATES FROM PATIENTS WITH MENINGITIS IN A PHARMACODYNAMIC MODEL SIMULATING THE CEREBROSPINAL-FLUID CONCENTRATION PROFILE, Antimicrobial agents and chemotherapy, 39(11), 1995, pp. 2560-2563
An in vitro pharmacodynamic model was used to determine the killing ki
netics of cefpirome against 20 Streptococcus pneumoniae strains (penic
illin G MICs, > 0.125 to 2 mu g/ml) isolated from patients with mening
itis. The concentration of cefpirome was adjusted dynamically to simul
ate the median concentration profile obtained in the cerebrospinal flu
id of adults after the infusion of a single dose of 2 g. The cefpirome
MIC at which 90% of isolates are inhibited was 0.5 mu g/ml. Bacterici
dal activity was observed at 6 h, with mean killing of 3.51 +/- 0.34 l
og(10) CFU/ml for all strains for which the cefpirome MIC was < 0.5 mu
g/ml. In contrast, for strains for which the cefpirome MIC was greate
r than or equal to 0.5 mu g/ml, killing was significantly less (P < 0.
05), with a mean reduction of only 2.86 +/- 0.57 log(10) CFU/ml.