GG167 ANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID) IS A POTENT INHIBITOR OF INFLUENZA-VIRUS IN FERRETS

Authors
RYAN DM TICEHURST J DEMPSEY MH
Citation
Dm. Ryan et al., GG167 ANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID) IS A POTENT INHIBITOR OF INFLUENZA-VIRUS IN FERRETS, Antimicrobial agents and chemotherapy, 39(11), 1995, pp. 2583-2584
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
11
Year of publication
1995
Pages
2583 - 2584
Database
ISI
SICI code
0066-4804(1995)39:11<2583:GAAIAP>2.0.ZU;2-4
Abstract
GG167 anidino-2,4-dideoxy-2,3-dehydro-N-acteylneuraminic acid) is a no vel viral neuraminidase (sialidase) inhibitor which, following intrana sal administration in ferrets, is at least 100 to 1,000 times more eff ective than ribavirin and amantadine against influenza A and B viruses . It retains its activity even when treatments are delayed until 24 h postinfection and has no effect on the serum antibody response to infe ction.