Ti. Nicas et al., ACTIVITIES OF THE SEMISYNTHETIC GLYCOPEPTIDE LY191145 AGAINST VANCOMYCIN-RESISTANT ENTEROCOCCI AND OTHER GRAM-POSITIVE BACTERIA, Antimicrobial agents and chemotherapy, 39(11), 1995, pp. 2585-2587
LY191145 is the prototype of a series of compounds with activities aga
inst vancomycin-resistant enterococci derived by modification of the g
lycopeptide antibiotic LY264826. LY191145 had MICs for vancomycin- and
teicoplanin-resistant enterococci of less than or equal to 4 mu g/ml
for 50% of isolates and less than or equal to 16 mu g/ml for 90% of is
olates. Its MICs for vancomycin-resistant, teicoplanin-susceptible ent
erococci were 1 to 8 mu g/ml. LY191145 retains the potent activities o
f its parent compound against staphylococci and streptococci. In vivo
studies in a mouse infection model confirmed these activities. This co
mpound indicates the potential of semisynthetic glycopeptides as agent
s against antibiotic-resistant gram-positive bacteria.