EXPRESSION OF C-FOS ONCOGENES IN ADRENAL-CORTEX OF THE RAT WITH RENAL-HYPERTENSION

This study was conducted using immunohistochemistry to detect the expr ession of the prooncogen c-fos in the corticoadrenal of the rat with r enal hypertension, A model of renal hypertension was established throu gh narrowing a renal artery of the rat, An antiserum against FOS oncop rotein was used to immunohistochemically detect the activated cells of the corticoadrenal. In the experimental group, C-FOS-immunoreactive ( ir) nuclei proved to be present in the zona glomerulosa, Few labeled n uclei were seen in the lateral part of the zona fasciculata, An increa sing number of G-FOS-ir nuclei was demonstrated in the intermediate pa rt of the zona fasciculata. The highest concentration of the labeled n uclei was found in the inner part of the zona fasciculata, Scattered F OS-ir nuclei existed in the zona reticularis. The labeled nuclei were often round or oval in shape, and different in size. Only were a few l abeled nuclei seen in the sham-operated group and no FOS-ir nuclei in normal control group. The result suggested that all three zones of the corticoadreal were modified subsequent to induction of renal hyperten sion.