METABOTROPIC GLUTAMATE RECEPTORS ARE INVOLVED IN TEA-INDUCED LONG-TERM POTENTIATION IN AREA CA1 OF THE HIPPOCAMPUS

Authors
PLATT B BEHNISCH T REYMANN KG
Citation
B. Platt et al., METABOTROPIC GLUTAMATE RECEPTORS ARE INVOLVED IN TEA-INDUCED LONG-TERM POTENTIATION IN AREA CA1 OF THE HIPPOCAMPUS, Neuropharmacology, 34(10), 1995, pp. 1339-1341
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
34
Issue
10
Year of publication
1995
Pages
1339 - 1341
Database
ISI
SICI code
0028-3908(1995)34:10<1339:MGRAII>2.0.ZU;2-I
Abstract
A brief application of the K+ channel blocker tetraethylammonium induc es a long-lasting potentiation in the CA1 region of hippocampal slices (TEA LTP). We report here that metabotropic glutamate receptors (mGlu Rs) contribute to this kind of synaptic enhancement, since the mGluR a ntagonist (+)-alpha-methyl-4-carboxyphenylglycine ((+) MCPG) inhibits TEA LTP with a concentration-dependent component.