ENDOTOXIN-INDUCED CELLULAR COMMUNICATION IN THE LIVER - MURINE MODELSFOR CLARIFICATION OF THE ROLE OF LPS-RESPONSIVE MACROPHAGES IN THE PATHOGENESIS OF LIVER-DISEASES

Authors
SHIRATORI Y KAWASE T KOMATSU Y HIKIBA Y OKANO K KAMII K OMATA M
Citation
Y. Shiratori et al., ENDOTOXIN-INDUCED CELLULAR COMMUNICATION IN THE LIVER - MURINE MODELSFOR CLARIFICATION OF THE ROLE OF LPS-RESPONSIVE MACROPHAGES IN THE PATHOGENESIS OF LIVER-DISEASES, Journal of gastroenterology and hepatology, 10, 1995, pp. 97-100
Citations number
32
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Journal of gastroenterology and hepatology → ACNP
ISSN journal
08159319
Volume
10
Year of publication
1995
Supplement
1
Pages
97 - 100
Database
ISI
SICI code
0815-9319(1995)10:<97:ECCITL>2.0.ZU;2-H
Abstract
In several experimental models, lipopolysaccharide (LPS) plays an impo rtant role in the pathogenesis of liver diseases. Murine models of C3H /HeN and C3H/HeJ mice have been used to elucidate the role of LPS and its responsive-macrophages in vivo, as C3H/HeN strain mice are known t o be LPS-responsive, while C3H/HeJ strain mice are LPS-resistant. Furt hermore, release of several kinds of biologically active mediators suc h as interleukin-1, tumour necrosis factor-alpha, colony stimulating f actor and reactive oxygen radical is not enhanced in C3H/HeJ mice even after stimulation with LPS. Thus, these murine models could be suitab le for clarification of endotoxin induced cellular communication in th e liver.