RAPID METHOD FOR COMBINED X-(H-1) NOE AND T-1 MEASUREMENT USING HETERONUCLEAR POLARIZATION TRANSFER

A polarization transfer enhanced inversion-recovery experiment is prop osed for the combined measurement of heteronuclear T-1 and NOE of low- gamma nuclei. This method offers significant time savings compared wit h conventional relaxation measurements, The reliability and accuracy o f the combined T-1 and NOE determination and its dependence on the exp erimental set-up is also demonstrated. The proposed approach may be pr eferred for multiple field/multiple temperature model-free analysis of molecular dynamics.