An unambiguous structural differentiation of B/C-cis- and B/C-trans-mo
rphinan derivatives (thebainone-A and beta-thebainone-A and their 7,8-
dihydro derivatives) is provided. The structures were confirmed by NOE
difference spectroscopy and selective 2D J-INEPT experiments. In addi
tion, full a priori H-1 and C-13 NMR assignments of the isomeric pairs
studied are presented.