ASYMMETRIC-SYNTHESIS OF BOTH ENANTIOMERS OF PYRROLIDINOISOQUINOLINE DERIVATIVES FROM L-MALIC ACID AND L-TARTARIC ACID

The pyrrolidinoisoquinoline derivatives ((-)-3, (-)-4) and their antip odes ((+)-3, (+)-4) were prepared by reductive deoxygenation and reduc tion from the intermediates 9 and 10. The key intermediates 9 and 10 w ere prepared by a diastereoselective N-acyliminium ion cyclization of chiral lactams, which derived from L-malic acid and L-tartaric acid, r espectively.