THE THIOFORMAMIDYL GROUP AS AN ALPHA-SUBSTITUENT IN CARBOCATIONS

Ab initio molecular orbital calculations at MP2(FULL)/6-311G(d,p) or M P2(FULL)/6-31G(d,p) are reported for carbocations RR'CCHO+, RR'CCHS+, RR'CCONH2+, and RR'CCSNH2+ where R and R' are H, CH3, c-C3H5, and C6H5 . Primary (R = R' = H), secondary (R = H, R' = alkyl or phenyl), and t ertiary (R = R' = CH3) ions prefer the cyclic oxiranyl or thiiranyl st ructure 9, with the open structure 8 being a transition structure for ring opening. Tertiary carbocations with R = R' = phenyl or cyclopropy l and the 9-thioformamidyl-9-fluorenyl cation have the open structure. Isodesmic reactions show CONH2 to be weakly stabilizing in the methyl cation, and CSNH2 has a larger stabilizing effect, roughly equivalent to that of a methyl group. An alpha-thioamide substituent is less sta bilizing in the ethyl cation and even less stabilizing in the isopropy l cation. In C6H5CHCSNH2+ the CSNH2 group is slightly destabilizing an d, by extrapolation, is more destabilizing in Ar2CCSNH2+. The rearrang ement of the alpha-thioformamidyl-benzyl cation to benzothiophene is c alculated to have a low barrier 15.4 kcal/mol at HF/6-31G(d,p).