COLLAGEN, ELASTIN AND GLYCOSAMINOGLYCANS IN AORTIC-ANEURYSMS

The walls of human abdominal aortas and atherosclerosis-induced aneury sms contain similar amounts of collagen. The quantitative ratio betwee n collagens of various types of this protein does not differ significa ntly either, whereas solubility of the collagen in aneurysmal wall and its susceptibility to the action of EDTA are distinctly decreased. In contrast with collagen, the amount of elastin in aneurysms is signifi cantly lower. Total amount of glycosaminoglycans slightly decreased as compared with that of normal tissue, but the ratio of particular comp ounds varies. The percentage of chondroitin sulphate is increased and that of heparan sulphate significantly decreased. The significance of these changes in pathogenesis of aneurysms is discussed.