SEVERE ARTERIAL THROMBOSIS IN A CONGENITALLY FACTOR-VII DEFICIENT PATIENT

We report a patient with congenital factor VII deficiency who develope d severe arterial thrombosis, A 63-year-old-woman presented low factor VII clotting activity, amidolytic activity and antigen level < 4%. Ac tivated factor VII plasmatic level was < 0.03 ng/ml compared to 4 ng/m l for the control value, She developed severe aorto-iliac thrombosis, 7 d before the thrombotic event, factor VII replacement therapy had be en infused, Successful low molecular weight heparin therapy led to tot al disappearance of the aorto-iliac thrombus without bleeding complica tions. This suggests that factor VII infusion might have a thrombogeni c effect in vivo and might be responsible for thrombosis.