X-RAY-ANALYSIS REVEALS CONFORMATIONAL ADAPTATION OF THE LINKER IN FUNCTIONAL CALMODULIN MUTANTS

Crystal structures of target peptide bound Ca2+-calmodulin linker heli x mutants with the helix shortened by two or th ree residues, or repla ced by the longer troponin C central helix, show that the major calmod ulin-target structure is preserved at the expense of linker conformati on.