Hypertension is, besides coronary artery disease, a main cause of hear
t failure (in about 40% of patients). About 20% of the adult German po
pulation are hypertensive. Increases in diastolic blood pressure by ab
out 5 mmHg increase the risk of stroke or coronary heart disease by ab
out 34% or 21%, respectively. As a cardiovascular risk factor systolic
hypertension is suggested to be at least as important as diastolic hy
pertension. Left ventricular hypertrophy is an independent cardiovascu
lar risk factor. Treatment of hypertension is first by general measure
s (weight loss, low-sodium diet, changes in lifestyle), and if necessa
ry by means of antihypertensive therapy with a diuretic, beta receptor
antagonist, calcium antagonist, or converting-enzyme inhibitor. Recen
t studies using thiazide diuretics gave support to the use of diuretic
s as a first line treatment of hypertension especially in patients wit
h isolated systolic hypertension or in elderly patients.