Seven patients with major depression who developed seizure inhibition
during a course of ECT, were given intravenous theophylline to increas
e seizure duration. Infusion of 100-200 mg of theophylline, administer
ed slowly over several minutes similar to 30 min before seizure induct
ion, was found to effectively and safely prolong seizure durations. In
a total of 55 treatment sessions, no cardiovascular or other complica
tions were seen. On one occasion, seizure duration was prolonged to 22
0 s.