We have observed the nucleation of bubbles in superfluid helium-4 at n
egative pressure and at temperatures down to 65 mK. Cavitation is foun
d to be a random process. Above 1 K, its probability varies with tempe
rature in a manner consistent with classical activation by thermal flu
ctuations. Below 0.4 K cavitation is still random but temperature inde
pendent, in agreement with a recent theory of quantum tunneling. We al
so consider another possible interpretation involving turbulence in th
e focal region.