MORPHOLOGICAL CHARACTERIZATION OF THE CELL-GROWTH INHIBITORY ACTIVITYOF ROOPEROL AND PHARMACOKINETIC ASPECTS OF HYPOXOSIDE AS AN ORAL PRODRUG FOR CANCER-THERAPY

Authors
ALBRECHT CF THERON EJ KRUGER PB
Citation
Cf. Albrecht et al., MORPHOLOGICAL CHARACTERIZATION OF THE CELL-GROWTH INHIBITORY ACTIVITYOF ROOPEROL AND PHARMACOKINETIC ASPECTS OF HYPOXOSIDE AS AN ORAL PRODRUG FOR CANCER-THERAPY, South African medical journal, 85(9), 1995, pp. 853-860
Citations number
17
Categorie Soggetti
Medicine, General & Internal
Journal title
South African medical journal → ACNP
ISSN journal
02569574
Volume
85
Issue
9
Year of publication
1995
Pages
853 - 860
Database
ISI
SICI code
0256-9574(1995)85:9<853:MCOTCI>2.0.ZU;2-K
Abstract
It can be concluded from these findings that rooperol has promising pr operties as an oral prodrug for cancer therapy in humans given its com plete first-pass metabolism into non-toxic conjugates which may be act ivated in tumours with high deconjugase activity. Rodent cancer models are, however, not applicable since rooperol metabolites are completel y sequestered in the bile.