MULTIVARIABLE NEUROPHYSIOLOGIC MONITORING - THE INFLUENCE OF BENZODIAZEPINE ANTAGONISTS ON SPECTRAL-ANALYSIS OF THE EEG AND MULTIMODAL EVOKED-POTENTIALS

We studied the effects of the benzodiazepine antagonists flumazenil an d the unspecific physostigmine on the EEG and on multimodal evoked pot entials with a multivariable monitoring system in three intensivecare patients. The monitoring system simultaneously and continuously record ed, processed and displayed a two-channel EEG, early and middle latenc y auditory evoked potentials, and early somatosensory evoked potential s. The effects of the two substances showed uniform reaction in spectr al analysis of the EEG. However, flumazenil showed various effects on the evoked potentials.