CRYORADIATION STERILIZATION - CONTEMPORARY STATE AND OUTLOOK

The new approach of radiation sterilization - cryoradiosterilization w ith programmed freezing was developed for pharmaceutical solutions. Bo th scientific and technical problems are solved, the results are discu ssed. Programmed freezing of vials with the drug's solutions provides the high stability of soluted components with biological activity at s terilizing irradiation without significant change of sterilization dos es. Physical, chemical, biological and pharmacological properties of a lot of drug solutions for injection satisfy official requirements aft er cryoradiation sterilization treatment. This method seems to be espe cially important for the protein systems which could be infected by da ngerous viruses (VIH, hepatitis B): blood plasma, diagnostic sera, pro tein preparations manufactured from donor's blood, etc.