A RECEPTOR INTERACTION-MODEL FOR PHENYLCARBAMATE LOCAL-ANESTHETICS

We report here a molecular modeling study of selected conformationally constrained phenylcarbamate local anesthetics in relation to the avai lable pharmacological data that enabled us to develop a receptor-inter action model for this class of drugs. The validity of the model was co nfirmed on other semirigid analogues prepared for-this study. The resu lts suggest that the phenyl ring is most likely involved in a stacking interaction with a complementary receptor site and the tertiary ammon ium group is capable of both hydrogen bonding and lipophilic interacti ons.