EFFECT OF PLATINUM(II) COMPLEXES OF BENZOIC AND 3-METHOXYBENZOIC ACIDHYDRAZIDES ON SACCHAROMYCES-CEREVISIAE

Authors
TABAKOVA S DODOFF N
Citation
S. Tabakova et N. Dodoff, EFFECT OF PLATINUM(II) COMPLEXES OF BENZOIC AND 3-METHOXYBENZOIC ACIDHYDRAZIDES ON SACCHAROMYCES-CEREVISIAE, Zeitschrift fur Naturforschung. C, A journal of biosciences, 50(9-10), 1995, pp. 732-734
Citations number
19
Categorie Soggetti
Biology
Journal title
Zeitschrift fur Naturforschung. C, A journal of biosciences → ACNP
ISSN journal
09395075
Volume
50
Issue
9-10
Year of publication
1995
Pages
732 - 734
Database
ISI
SICI code
0939-5075(1995)50:9-10<732:EOPCOB>2.0.ZU;2-7
Abstract
The inhibitory effect of benzoic acid hydrazide (bah) and 3-methoxyben zoic acid hydrazide (mbah) on Saccharomyces cerevisiae strains has bee n compared to that of their platinum(II) complexes: cis-[Pt(bah)(2)X(2 )], cis[Pt(NH3)(bah)Cl-2]. 0.5H(2)O, cis-[Pt(mbah)(2)X(2)] and cis-[Pt (NH3)(mbah)Cl-2] (X = Cl, Br = I), and cis-[Pt(NH3)(2)Cl-2]. The minim al inhibitory concentrations for bah and mbah were 5000-20,000 mu M wh ereas for their Pt(II) complexes they were much less (25-800 mu M) and did not exceed these of cisplatin (100-500 mu M). The activity of the Pt(II) complexes of bah and mbah varied in wide ranges for the differ ent yeast strains tested. Osmotically unstable mutants were found to b e more susceptible. The most active complexes were [Pt(NH3)(bah)Cl-2]. 0.5H(2)O and [Pt(NH3)(mbah)Cl-2].