Intra-articular morphine has been shown to provide prolonged analgesia
after arthroscopic knee surgery; the addition of local anaesthetic ag
ents has been reported to improve this analgesic effect. Pethidine pos
sesses local anaesthetic properties, and therefore this study was desi
gned to evaluate its analgesic efficacy after arthroscopic meniscectom
y. Sixty patients were allocated randomly to receive intra-articular i
njections of pethidine 50 mg, morphine 5 mg or saline after elective a
rthroscopic meniscectomy. Postoperative pain was assessed using an int
erval visual analogue scale and measuring analgesic requirements. Both
treatment groups had significantly lower pain scores compared with th
e control group. Patients in the pethidine group had lower pain scores
than those in the morphine group at 0.5, 1 and 2 h, but significantly
higher scores at 12 and 24 h. These observations suggest that the loc
al anaesthetic effect of pethidine may be responsible for the improved
early analgesia, but its duration of action appears to be less than t
hat of morphine.