Sixty (29%) of 205 consecutive patients with transient ischemic attack
s registered in a hospital stroke data base had headache within 72 hou
rs of onset. Headache was significantly more common in nonsmokers (odd
s ratio = 2.8; 95% confidence interval = 6.7 to 1.2). Headache was inf
requent in patients with amaurosis fugax, and was not significantly as
sociated with any other particular clinical presentation of transient
ischemic attack. Headache was more common in vertebrobasilar (33%) tha
n in carotid distribution (24%) episodes, and was not rare in transien
t ischemic attacks presenting as lacunar syndromes (29%). Headache was
less frequent in patients whose computerized tomograms showed an infa
rct appropriate to the symptoms (odds ratio = 0.2; 95% confidence inte
rval = 0.02 to 1.4). A diffuse headache was more common in patients wi
th lacunar events than in patients with cortical attacks (odds ratio =
3.0; 95% confidence interval = 13 to 0.07). No other association was
found between headache location and the presumed involved vascular ter
ritory. Headache in patients with transient ischemic attacks is poorly
related/explained by the clinical characteristics of the ischemic eve
nt.