We present the case of a man with new onset of migraine with aura as t
he presenting sign of acute promyelocytic leukemia and disseminated in
travascular coagulation. This previously unreported association may su
pport theories of platelet serotonin involvement in the pathogenesis o
f migraine. It would be valuable in the future to evaluate other patie
nts with disseminated intravascular coagulation or acute promyelocytic
leukemia for the presence of migrainous auras or headaches, symptoms
which may be underreported by patients, particularly in the setting of
severe illness.