The chemistry and biology of novel TXA(2)(TP)-receptor agonists based
on the prostanoid skeleton is described and structure-activity-relatio
n ships are discussed. One compound, (5Z,13E), 16-phenoxy-17,18,19,20-
tetranor-5,13-prostadienoic acid (33), was identified which is 10 time
s more potent than the standard TP-receptor agonist U 46619.