NOVEL PROSTANOID THROMBOXANE A(2) AGONISTS

Authors
JOACHIM KD KLAR U PLETSCH A REHWINKEL H SKUBALLA W
Citation
Kd. Joachim et al., NOVEL PROSTANOID THROMBOXANE A(2) AGONISTS, Prostaglandins, 50(2), 1995, pp. 57-63
Citations number
12
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Prostaglandins → ACNP
ISSN journal
00906980
Volume
50
Issue
2
Year of publication
1995
Pages
57 - 63
Database
ISI
SICI code
0090-6980(1995)50:2<57:NPTAA>2.0.ZU;2-K
Abstract
The chemistry and biology of novel TXA(2)(TP)-receptor agonists based on the prostanoid skeleton is described and structure-activity-relatio n ships are discussed. One compound, (5Z,13E), 16-phenoxy-17,18,19,20- tetranor-5,13-prostadienoic acid (33), was identified which is 10 time s more potent than the standard TP-receptor agonist U 46619.