LONGITUDINAL-STUDY OF SERUM AND CEREBROSPINAL-FLUID (CSF) CLASS-SPECIFIC ANTIBODIES AGAINST CAMPYLOBACTER-JEJUNI AND GM1 GANGLIOSIDE IN GUILLAIN-BARRE-SYNDROME

We report two Guillain-Barre Syndrome (GBS) patients with culture-prov en Campylobacter jejuni (Pener 19/Lior 7). Elevated anti-C.jejuni IgA antibody declined to the normal range within one month, elevation of a nti-C.jejuni IgM antibody lasted for 3 months and the titers of anti-C .jejuni IgG antibody were still elevated at one year after the neurolo gic onset. Serological criteria for antecedent C.jejuni infection in G BS patients should require 1) high titer of serum IgA and/or IgM antib ody against C.jejuni followed by seroconversion of the IgA and/or IgM and 2) a 4-fold decline of IgG serum dilution against C.jejuni. Anti-C .jejuni antibodies in cerebrospinal fluid (CSF) reached the maximum va lue at one month after their neurologic onset which may not be respons ible for the main pathological mechanism in the development of GBS. An ti-GM1 antibodies in serum and CSF were parallel with those of anti-C. jejuni antibodies during the course of the disease,