THE EFFECT OF NOREPINEPHRINE AND DOBUTAMINE ON BLADDER EPITHELIAL OXYGEN-TENSION

Citation
Dm. Rosser et al., THE EFFECT OF NOREPINEPHRINE AND DOBUTAMINE ON BLADDER EPITHELIAL OXYGEN-TENSION, Chest, 108(5), 1995, pp. 1368-1372
Citations number
27
Categorie Soggetti
Respiratory System
Journal title
ChestACNP
ISSN journal
00123692
Volume
108
Issue
5
Year of publication
1995
Pages
1368 - 1372
Database
ISI
SICI code
0012-3692(1995)108:5<1368:TEONAD>2.0.ZU;2-4
Abstract
Study objectives: To assess the effects of two contrasting vasoactive agents (dobutamine [DOB] and norepinephrine [NE]) on (1) global and re gional cardiorespiratory variables, (2) acid base status, and (3) blad der epithelial oxygen tension (BEOT), a putative marker of organ perfu sion. Design: Measurement of aortic blood flow (ABF) and renal blood f low (RBF), mean arterial blood pressure, arterial blood gases, and BEO T were made during infusion of placebo and varying doses of DOB and NE . Setting: Medical school laboratory. Subjects: Eighteen anesthetized, spontaneously breathing, male Sprague-Dawley rats divided into three groups, Interventions: Two groups were allocated to receive escalating doses of DOE (to 40 mu g/kg/min) or NE (to achieve a 50% change in an y hemodynamic variable), The drug therapy was then discontinued for 15 min and restarted at the previous maximum dose, A third group receive d 0.9% saline solution at the same infusion rate (16 mL/kg/h). Measure ments and results: There was a dose-related increase in mean blood pre ssure with NE and fall with DOB. Compared with control values, NE had no effect on ABF but decreased RBF significantly whereas DOB significa ntly increased ABF: but had no effect on RBF. Base excess and BEOT dec reased significantly and in parallel with both agents, more so with NE . Conclusions: Despite their different macrocirculatory effects, DOB a nd NE both produced a significant but reversible fall in BEOT and a me tabolic acidosis, BEOT shows potential as a monitor of die effectivene ss of organ perfusion.