Purpose: To measure the relative effect of cataract surgery in the sec
ond eye compared with the first eye on functional impairment, satisfac
tion, and vision problems. Methods: Seventy-five randomly selected oph
thalmologists in three cities in the United States were enrolled in a
National Study of Cataract Outcomes. They, in turn, referred eligible,
sequential patients scheduled for first-eye cataract surgery. Intervi
ews were conducted at enrollment, 4 months after first-eye surgery, an
d 12 months after first-eye surgery. An attempt was made to conduct a
special, preoperative interview of those patients scheduled to undergo
second-eye surgery before the 4-month interview. Each interview inclu
ded administration of the VF-14 (a 14-item questionnaire that assessed
visual function), as well as questions about symptoms possibly relate
d to cataract, ''trouble with vision,'' and satisfaction with vision.
Results: Seven hundred seventy-two patients were enrolled in the study
, and interview data to 12 months were obtained from 669 (86%) patient
s. Of these patients, 243 (36%) underwent cataract extraction in the s
econd eye during the 12-month period of observation. Overall, subjects
who underwent cataract surgery in both eyes during the 12-month perio
d had 61% greater improvement in VF-14 score (P < 0.001), 27% more dec
line in trouble with vision (P < 0.001), and 24% greater improvement i
n satisfaction with vision (P < 0.001) compared with those who underwe
nt surgery in only one eye. Conclusions: Cataract surgery in the secon
d eye of patients with bilateral cataract is associated with clinicall
y and statistically significant improvement in functional impairment,
trouble with vision, and satisfaction with vision.