Wj. Power et al., ANALYSIS OF THE ACUTE OPHTHALMIC MANIFESTATIONS OF THE ERYTHEMA MULTIFORME STEVENS-JOHNSON SYNDROME TOXIC EPIDERMAL NECROLYSIS DISEASE SPECTRUM, Ophthalmology, 102(11), 1995, pp. 1669-1676
Purpose: To evaluate the epidemiology, possible etiologic factors, com
plications encountered, and treatment administered to a group of patie
nts with ocular involvement in the erythema multiforme/Stevens-Johnson
syndrome/toxic epidermal necrolysis disease spectrum who were seen at
two large tertiary referral centers over a 34-year period. Methods: H
ospital records from 1960 to 1994 at the Massachusetts General Hospita
l and Shriners Hospital for Crippled Children were reviewed for patien
ts with erythema multiforme, Stevens-Johnson syndrome, or toxic epider
mal necrolysis. Only patients fulfilling specific clinical diagnostic
criteria and those who received a diagnosis by a dermatologist were in
cluded in the review. Results: A total of 366 patients with erythema m
ultiforme, Stevens-Johnson syndrome, or toxic epidermal necrolysis wer
e identified. Drugs were the most commonly identified etiologic factor
in all three conditions; sulfonamides were the most frequently identi
fied agents. Eighty-nine patients (24%) had ocular manifestations at t
he time of their acute hospital stay. Ocular involvement was seen in 9
% of patients with erythema multiforme, in 69% with Stevens-Johnson sy
ndrome, and in 50% with toxic epidermal necrolysis. The ocular problem
s were more severe in patients with both Stevens-Johnson syndrome and
toxic epidermal necrolysis. There was no significant difference betwee
n the number of patients who were treated with systemic steroids and t
hose who were not (P = 0.42). Conclusion: The erythema multiforme/Stev
ens-Johnson syndrome/toxic epidermal necrolysis disease spectrum remai
ns an important cause of severe visual loss in a significant number of
patients. Systemic steroids used during the acute phase of the diseas
e appear to have no effect on the development of ocular manifestations
. Studies on the acute immunopathogenic mechanisms occurring in these
diseases are warranted if more effective therapies are to be found.