A NEW ROUTE FOR THE SYNTHESIS OF 1,2,4-TRIAZOLE AND 3,4-DISUBSTITUTEDCINNOLINE DERIVATIVES

The behaviour of 4-aryl-hydrzono-2-phenyl-2-oxozolin-5-one towards phe nols, aromatic amines, 1,2,4-triazol-5-amino and acylhydrazines to giv e the 1,2,4-triazol derivatives have been studied. Fries rearrangement products have been obtained by refluxing the products resulting from the starting material and phenols or amines with anhydrous zinc chlori de and acetic acid. Reactions of Fries rearrangement products with mal ononitrile have also been studied. Interestingly, reaction of oxazolin one derivative with or without acetophenone give one and the same prod uct benzoylamino-6-methyl-cinnolin-4-ol. The mechanism of the later re action has been discussed. The structure of the products has been stud ied by different spectroscopic methods.